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The Study of Stability and Location of Chloramphenicol in Newly Formed Microemulsion Based Ocular Drug Delivery System

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ARTICLE DOWNLOAD

The Study of Stability and Location of Chloramphenicol in Newly Formed Microemulsion Based Ocular Drug Delivery System

10$

Tehreem Naz, Sadia Nazir, Muhammad Abid Rashid, Muhammad Nadeem Akhtar, Muhammad Usman, Madeha Abbas & Ghulam Abbas 

Microemulsions (MEs) are homogeneous, optically clear and thermodynamically stable systems intended to increase the bioavailbility, solubility, and entrapment of drugs. Anew system of oil-in-water MEs was formulated for the entrapment of chloramphenicol, consisting of isopropyl myristate/Tween 60/80 with short-chain alcohol and phosphate buffer (pH 7). The 1H NMR spectroscopy was used for investigation of the drug location in formulation. The drug is entrapped in a hydrophilic shell of ME, which consists of oxyethylene groups. It was revealed by 1H NMR study that the drug stability increases due to its screening from bulk water. The formulated MEs were evaluated for the phase composition, pH, refractive index, conductivity, surface tension, partition coefficient, and viscosity. These characteristics suggested that the optimized MEs were stable and optically clear and could be used as an efficient ocular drug carrier.

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Year 2020
Language English
Format PDF
DOI 10.1007/s11094-020-02120-2