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Synthesis of New Bis(Indolyl)Methanes Catalyzed by Benzylsulfamic Acid and Evaluation of Their Antimicrobial Activities

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ARTICLE DOWNLOAD

Synthesis of New Bis(Indolyl)Methanes Catalyzed by Benzylsulfamic Acid and Evaluation of Their Antimicrobial Activities

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Sara Soltani, Naser Montazeri, Masoud Mohammadi Zeydi & Majid M. Heravi 

Benzylsulfamic acid has been prepared and introduced as a new heterogeneous acid catalyst. This reagent was used for the synthesis of new bis(indolyl)methanes 3a – 3f via reaction of bis-aldehydes 1 with indoles 2 at 100°C. All reactions were performed under solvent-free conditions with high to excellent yields. The synthesized bis(indolyl)methanes were evaluated for their antibacterial and antifungal activities.

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Year 2020
Language English
Format PDF
DOI 10.1007/s11094-020-02103-3