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Surgery for Pheochromocytoma: A Single-Center Review of 60 Cases from South Africa

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ARTICLE DOWNLOAD

Surgery for Pheochromocytoma: A Single-Center Review of 60 Cases from South Africa

10$

D. Nel, E. Panieri, F. Malherbe, R. Steyn & L. Cairncross 

Abstract

Background

There is a paucity of data on the presentation and surgical management of pheochromocytoma in developing nations, particularly in Africa.

Methods

This study was a retrospective review, which included all patients managed by the Groote Schuur Hospital/University of Cape Town Endocrine Surgery unit for pheochromocytoma and abdominal paragangliomas, from January 2002 to June 2019.

Results

Sixty patients were included in the study, of which 33% were male and 67% female. The mean age was 47 years (range 14–81). The median tumor size was 6 cm, with 45% larger than 6 cm. 92% were located in the adrenal gland (87% unilateral, 5% bilateral), and 8% were extra-adrenal. The conversion rate for laparoscopic cases was 20%, with 55% of cases overall completed laparoscopically. Eleven patients with tumors > 6 cm were initially attempted laparoscopically, of which 3 were converted to open, without any associated increased morbidity. A major adverse event was recorded for 5 cases (8%), including 1 mortality. Overall morbidity, blood loss, operating time and hospital stay were all significantly reduced in the laparoscopic group. There were 5 patients with malignant disease (8%).

Conclusion

This large series, from an established academic endocrine surgery unit in Africa, can serve as a benchmark for units with similar settings and resource limitations, to compare their surgical management and perioperative outcomes.

Only units of this product remain
Year 2020
Language English
Format PDF
DOI 10.1007/s00268-020-05420-6