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Substituted coumarins as ambident nucleophiles in one-pot hydrogenation/alkylation reaction

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ARTICLE DOWNLOAD

Substituted coumarins as ambident nucleophiles in one-pot hydrogenation/alkylation reaction

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Nevena I. Petkova-Yankova & Rositca D. Nikolova 

Abstract

The regioselectivity of a one-pot hydrogenation/alkylation reaction of coumarins 1a and 1b with series of alkyl halides has been elucidated as a complementary work to reaction of acylation with the same coumarins. Reaction conditions have provided formation of only C-alkylation products with good to high yield. The results from the experiments are of significant importance to predict reactivity of 3-substituted coumarins in different reaction conditions.

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Year 2020
Language English
Format PDF
DOI 10.1007/s11696-020-01098-1