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Principles and applications of nanomaterial-based hyperthermia in cancer therapy

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ARTICLE DOWNLOAD

Principles and applications of nanomaterial-based hyperthermia in cancer therapy

10$

Jin Kook Kang, Jae Chang Kim, Yuseon Shin, Sang Myung Han, Woong Roeck Won, Jaewon Her, June Yong Park & Kyung Taek Oh 

Abstract

Over the past few decades, hyperthermia therapy (HTT) has become one of the most promising strategies to treat cancer. HTT has been applied with nanotechnology to overcome drawbacks such as non-selectivity and invasiveness and to maximize therapeutic efficacy. The high temperature of HTT induces protein denaturation that leads to apoptosis or necrosis. It can also enhance the effects of other cancer therapies because heat-damaged tissues reduce radioresistance and help accumulate anticancer drugs. Gold nanoparticles and superparamagnetic iron oxide with different energy sources are commonly used as hyperthermia agents. New types of nanoparticles such as those whose surface is coated with several polymers and those modified with targeting moieties have been studied as novel HTT agents. In this review, we introduce principles and applications of nanotechnology-based HTT using gold nanoparticles and superparamagnetic iron oxide.

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Year 2020
Language English
Format PDF
DOI 10.1007/s12272-020-01206-5