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Our experience of repeat laparoscopic liver resection in patients with recurrent hepatocellular carcinoma

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ARTICLE DOWNLOAD

Our experience of repeat laparoscopic liver resection in patients with recurrent hepatocellular carcinoma

10$

Hisataka Ogawa, Shin Nakahira, Masashi Inoue, Toshimitsu Irei, Makoto Hasegawa, Kazuya Kato, Keisuke Oyama, Hoshi Himura, Takayuki To, Ryosuke Maki, Hidemi Nishi, Nobuyoshi Ohara, Jota Mikami, Yoichi Makari, Ken Nakata, Masaki Tsujie & Junya Fujita 

Abstract

Background

Repeat liver resection is an effective treatment approach for patients with recurrent hepatocellular cell carcinoma (HCC). However, the surgical feasibility and oncological significance of repeat laparoscopic liver resection (r-LLR) remain unproven. This study evaluates and compares the clinical outcomes of non-anatomic r-LLR applied towards recurrent HCC, with those of primary LLR (p-LLR) for primary HCC.

Methods

This retrospective study reports 104 patients with HCC, treated with LLR between 2014 and 2018. Twenty eight of these patients underwent r-LLR for recurrent HCC. The clinical and surgical variables were reviewed for all cases.

Results

The analysis was limited to non-anatomic resection across both groups (r-LLR: 89% (25/28) vs. p-LLR: 80% (61/76)). There were no statistically significant differences about patient background between the two groups, with the exception of Child–Pugh classification. r-LLR surgical techniques included single-site laparoscopic adhesiolysis (32%, 8/25), Pringle maneuver (8%, 2/25), and crush–clamp method using BiClamp for hepatic parenchymal transection (72%, 18/25). No severe postoperative complications were observed in the r-LLR group. Postoperative hospital stays and procedure-related postoperative survival were similar for both groups.

Conclusions

Non-anatomical r-LLR renders comparable surgical and oncological outcomes. Our data suggest that non-anatomical r-LLR is a safe and feasible therapeutic approach to recurrent HCC.

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Year 2020
Language English
Format PDF
DOI 10.1007/s00464-019-06992-8