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Formulation of a Jasmine Grandiflorum containing mucoadhesive and evaluation of its healing effect on oral biopsy ulcers

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ARTICLE DOWNLOAD

Formulation of a Jasmine Grandiflorum containing mucoadhesive and evaluation of its healing effect on oral biopsy ulcers

10$

Hamed Mortazavi, Fatemeh Mashhadiabbas, Seyed Ali Reza Mortazavi, Kosar Rezaeifar & Mahdieh Farhangi 

Abstract

Objectives

The present research aimed to explore the effect of a mucoadhesive containing Jasminum grandiflorum leaves on the process of oral wound healing in animal samples.

Materials and methods

The present double-blinded research was conducted on animals. To this aim, 28 rats were randomly selected and assigned to groups of control and experiment. The lesion was created by punch no. 3 in the midline of the mandibular labial mucosa of all mice. Each group received either a medicine or a placebo exclusively coded. The extent of contraction and wound healing was clinically assessed. To compare the two research groups, chi-squared test, repeated-measure ANOVA, and Mann-Whitney U test were run. SPSS software was used to do the statistical analyses.

Results

Statistically significant differences were found between the percentage of wound contraction on the 3rd day (40.91% vs. 16.5%, p = 0.04) and the 7th day (92.9% vs. 69.2%, p = 0.05), wound recovery (57.1% vs. 21.4%, p = 0.05) and degree of inflammation on the 7th day (p = 0.00), type (p = 0.04) and thickness of epithelium (p = 0.00) and type of connective tissue (p = 0.00) on the 14th day.

Conclusion

Investigations showed that the drug was more effective than the placebo in accelerating wound healing in clinical and histopathological terms.

Clinical relevance

Accelerating wound healing in dental treatments and oral ulcers can also affect the quality of life of individuals.

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Year 2020
Language English
Format PDF
DOI 10.1007/s00784-019-03171-w