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Express analysis of amoxicillin via colorimetric testing

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ARTICLE DOWNLOAD

Express analysis of amoxicillin via colorimetric testing

10$

Anastasia V. Marakaeva & Irina V. Kosyreva 

Abstract

Falsified drugs are a serious problem of modern society. Therefore, it is necessary to develop a fast and simple method of drug screening for checking of their falsification. In this article, we present paper-based test methods that can be used to identify amoxicillin, a β-lactam series antibiotic agent, used the mobile phone camera. The detection time is 10 min. Ninhydrin, p-dimethylaminobenzaldehyde, and Fehling’s reagent are used as reagents for the test. We have found out the optimal conditions of express analysis, including temperature and duration of heating. We have obtained the color scales for visual and colorimetric detection of the antibiotic agent. Optimal color parameters for RGB, CMYK, and HSV color models have been analyzed. We have demonstrated linear correlations between optimal colorimetric parameters and antibiotic agent concentration. Profiles of radar diagrams using color parameters as coordinates are obtained. Linear correlation between area and perimeter of radar diagrams and amoxicillin concentration was found.

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Year 2020
Language English
Format PDF
DOI 10.1007/s11696-020-01085-6