ARTICLE DOWNLOAD

Edoxaban affects TRAP-dependent platelet aggregation

10$
ARTICLE DOWNLOAD

Edoxaban affects TRAP-dependent platelet aggregation

10$

Frantisek Nehaj, Juraj Sokol, Jela Ivankova, Michal Mokan, Marian Mokan & Jan Stasko 

Abstract

Edoxaban is an oral anticoagulant drug and a direct factor Xa inhibitor. However, it is still not fully understood if and how edoxaban impacts platelet function. This prospective study aimed to assess in vitro platelet function in patients with atrial fibrillation (AF) receiving edoxaban. It was a single centre study quantifying platelet aggregation in 20 patients treated with edoxaban by light transmission aggregometry. The thrombin receptor activating peptide (TRAP)-induced platelet aggregation was significantly lower 2 h after taking edoxaban compared to baseline value (44.7 ± 32.03% vs. 73.3 ± 25.55%; p < 0.0001). In addition, we did not find any significant difference in results between the patient groups.

The TRAP-induced platelet aggregation is reduced in non-valvular AF patients receiving edoxaban.

Only units of this product remain
Year 2020
Language English
Format PDF
DOI 10.1007/s11239-020-02093-9