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Analysis of pituitary transcriptomics indicates that lncRNAs are involved in the regulation of sheep estrus

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ARTICLE DOWNLOAD

Analysis of pituitary transcriptomics indicates that lncRNAs are involved in the regulation of sheep estrus

10$

Xiaoyue Li, Cunyuan Li, Yueren Xu, Rui Yao, Huixiang Li, Wei Ni, Renzhe Quan, Mengdan Zhang, Li Liu, Shuting Yu, Yaseen Ullah, Ruirui Hu, Yaxin Li, Tao Guo, Xiaokui Wang & Shengwei Hu 

Abstract

Seasonal estrus is a key factor limiting animal fertility, and understanding the molecular mechanisms that regulate animal estrus is important for improving animal fertility. The pituitary gland, which is the most important endocrine gland in mammals, plays an important role in regulating the physiological processes such as growth, development, and reproduction of animals. Here, we used RNA-seq technology to study the expression profile of lncRNAs in the anterior pituitary of sheep during estrus and anestrus. In this study, we identified a total of 995 lncRNAs, of which 335 lncRNAs were differentially expressed in two states (including 38 up-regulated and 297 down-regulated lncRNAs). RT-qPCR verified the expression levels of several lncRNAs. Target predictive analysis revealed that these lncRNAs can act in cis or trans and regulate the expression of genes involved in the regulation of sheep estrus. Target gene enrichment analysis of differentially expressed lncRNAs indicates that these lncRNAs can regulate sheep estrus by regulating hormone metabolism and energy metabolism. Through our research, we provide the expression profile of lncRNAs in the pituitary of sheep, which provides a valuable resource for further understanding of the genetic regulation of seasonal estrus in sheep from the perspective of lncRNAs.

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Year 2020
Language English
Format PDF
DOI 10.1007/s10142-020-00735-y